Real-Time Quantification of Low-Dose Cohesive Formulations within a Sampling Interface for Flowing Powders
Contributor(s):: Sierra-Vega, Nobel. O., Romañach, Rodolfo J., Mendez, Rafael
This study investigates the performance of a sampling interface for monitoring cohesive, flowing powder formulations with Hausner's Ratio and Carr's Index higher than 1.5 and 35%, respectively. The sampler device was operated in combination with near-infrared (NIR) spectroscopy to quantify...
In-line monitoring of low drug concentration of flowing powders in a new sampler device
Contributor(s):: Sierra-Vega, Nobel O, Méndez, Rafael, Martínez-Cartagena, Pedro; Alvarado-Hernández, Bárbara B; Romañach, Rodolfo J.
A novel sampler device for flowing powders was tested to quantify drug concentrations as low as 0.76% w/w in pharmaceutical powder blends. The sampler device was developed based on the powder flow behavior within a tablet press feed frame, following the principles laid down in the Theory of...