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1. Process Intensification of a Napabucasin Manufacturing Method Utilizing Microflow Chemistry

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   10 May 2024 | Contributor(s):: Usutani, Hirotsugu, Yamamoto, Kenji, Hashimoto, Kazuki

   Microflow chemistry is one of the newest and most efficient technologies used today for the safe and effective production of medicines. In this paper, we show the use of this technology in the development of a manufacturing method for napabucasin, which has potential in the treatment of...

2. Application of Continuous Flow Micromixing Reactor Technology for Synthesis of Benzimidazole Drugs

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   24 Apr 2024 | Contributor(s):: Reddy, Gunupati Sharathchandra, Reddy, Narra Santosh, Manudhane, Kushal, Rama Krishna, Medisetti Venkata, Ramachandra, Kopparapu Janardana Sarma, Gangula, Srinivas

   Synthesis of pharmaceutically active compounds by employing continuous flow micromixing reactor technology is an interesting research area. In this article we describe the synthesis of benzimidazole core drugs, such as lansoprazole (1a), pantaprazole (1b), and rabeprazole (1c) by using a...