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Scale-Up of a Continuous Manufacturing Process of Edaravone
10 May 2024 | Contributor(s):: Zhou, Shuhao, Hong, Qingxia, Mei, Wenliu, He, Yan, Wu, Chengjun, Sun, Tiemin
Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day...
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Application of Continuous Flow in Tazobactam Synthesis
24 Apr 2024 | Contributor(s):: Zhou, Shuhao, Xin, Yunting, Wang, Jiasheng, Wu, Chengjun, Sun, Tiemin
Tazobactam is a β-lactamase inhibitor. In this work, a combination of continuous flow and batch experiments for the synthesis of tazobactam has been developed. The first three steps and the preparation of the peroxyacetic acid are continuously carried out in the microreactors, which improves the...
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Process Modeling Issues in the Design of a Continuous-Flow Process for the Production of Ibuprofen
09 Jun 2023 | Contributor(s):: Tripodi, A, Martinazzo, RRamis, G, Rossetti, I
The continuous-flow production of active pharmaceutical ingredients is a spreading applicative Research Article field. Process simulation tools are effective means for in silico process design, but care is needed. A paradigmatic example is the synthesis of ibuprofen. First, the most appropriate...
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Micro reactor and flow chemistry for industrial applications in drug discovery and development
09 Jun 2023 | Contributor(s):: Baraldi, PT, Hessel, V
In this review, case studies focused on syntheses of active pharmaceutical ingredients, intermediates and lead compounds are reported employing micro reactors and continuous flow technology in areas such as medicinal chemistry, chemical development and manufacturing. The advantages of flow...
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Forbidden Chemistries - Paths to a Sustainable Future Engaging Continuous Processing
09 Jun 2023 | Contributor(s):: Gutmann, B, Kappe, CO
Optimizing current chemical processes alone does not yield the improvements required in the fine chemical and pharmaceutical industries. At least partially, a switch from batch to continuous manufacturing is needed. Cost-, time-, and atom-efficient routes frequently demand the application of high...
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Flow chemistryMicroreaction technology comes of age
09 Jun 2023 | Contributor(s):: Jensen, KF
Over the past two decades, microreaction technology has matured from early devices and concepts to encompass a wide range of commercial equipment and applications. This evolution has been aided by the confluence of microreactor development and adoption of continuous flow technology in organic...
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Flow Processing as a Tool for API Production in Developing Economies
09 Jun 2023 | Contributor(s):: de;Souza, ROMA, Watts, P
In this perspective article, the use of continuous flow synthesis to prepare advanced pharmaceutical intermediates in developing economies is highlighted. Case studies are presented to suggest that cost effective local manufacture of life saving drugs, may potentially be implemented to facilitate...
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Continuous-Flow Technology—A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients
09 Jun 2023 | Contributor(s):: Gutmann, B, Cantillo, D, Kappe, CO
In the past few years, continuous-flow reactors with channel dimensions in the micro- or millimeter region have found widespread application in organic synthesis. The characteristic properties of these reactors are their exceptionally fast heat and mass transfer. In microstructured devices of...