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Why We Need Continuous Pharmaceutical Manufacturing and How to Make It Happen
09 Jun 2023 | Contributor(s):: Clive Badman, Charles L.Cooney, Alastair Florence, Konstantin Konstantinov, Markus Krumme, Salvatore Mascia, Moheb Nasr, Bernhardt L. Trout
We make the case for why continuous pharmaceutical manufacturing is essential, what the barriers are, and how to overcome them. To overcome them, government action is needed in terms of tax incentives or regulatory incentives that affect time.
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Recent Progress in Continuous Crystallization of Pharmaceutical Products: Precise Preparation and Control
09 Jun 2023 | Contributor(s):: Ma, Yiming, Joao Macaringue, Estevao, Zhang, Teng, Gong, Junbo, Wu, Songgu, Wang, Jingkang
Crystallization, as a solid−liquid separation process, is employed to purify and isolate a great diversity of crystalline pharmaceutical products. In recent years, continuous crystallization has attracted increasing attention because of the product and process robustness as well as higher...
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
09 Jun 2023 | Contributor(s):: Pauli, Victoria, Kleinebudde, Peter, Krumme, Markus
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production. One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase...
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Optimized continuous pharmaceutical manufacturing via model-predictive control
09 Jun 2023 | Contributor(s):: Rehrl, Jakob, Kruisz, Julia, Sacher, Stephan, Khinast, Johannes, Horn, Martin
This paper demonstrates the application of model-predictive control to a feeding blending unit used in continuous pharmaceutical manufacturing. The goal of this contribution is, on the one hand, to highlight the advantages of the proposed concept compared to conventional PI-controllers, and, on...
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Model-Based Control-Loop Performance of a Continuous Direct Compaction Process
09 Jun 2023 | Contributor(s):: Ramachandran, Rohit, Arjunan, Jeyrathan, Chaudhury, Anwesha, Ierapetritou, Marianthi G
This study is concerned with enhanced model-based control of a continuous direct compression pharmaceutical process. The control-loop performance is assessed in silico and results obtained will be incorporated into the pilot plant facility of the continuous direct compaction process at the NSF...
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Anti-fouling control of plug-flow crystallization via heating and cooling cycle
09 Jun 2023 | Contributor(s):: Koswara, Andy, Nagy, Zoltan K.
Plug-flow crystallization (PFC) is a promising continuous pharmaceutical crystallization process but is prone to fouling due to uncontrolled crystallization on the reactor surface (encrustation). This results in operational issues such as (1) flow blockage, (2) increased thermal resistance, and...