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Model-predictive design, control and optimization of pharmaceutical process
09 Jun 2023 | Contributor(s):: Muzzio, F, Singh, R Chaudhury, A Rogers, A Ramachandran, R, Ierapetritou, M
Applying model-predictive methods and a continuous process-control framework to a continuous tablet-manufacturing process. Currently, there is a high level of interest in the pharmaceutical industry in continuous-manufacturing strategies, integrated with online-monitoring tools, that are...
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Model-Predictive Design, Control, and Optimization
09 Jun 2023 | Contributor(s):: Muzzio, Fernando, Singh, Ravendra Chaudhury, Anwesha Rogers, Amanda Ramachandran, Rohit, Ierapetritou, Marianthi
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Modeling and simulation studies of a novel coupled plug flow crystallizer for the continuous separation of conglomerate-forming enantiomers
09 Jun 2023 | Contributor(s):: Majumder, Aniruddha
Separation of enantiomers is a major concern in pharmaceutical industries due to the different therapeutic activities exhibited by the enantiomers. Preferential crystallization is an attractive means to separate the conglomerate-forming enantiomers. In this work, a simulation study is presented...
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Mathematical modeling and digital design of an intensified filtration-washing-drying unit for pharmaceutical continuous manufacturing
09 Jun 2023 | Contributor(s):: Destro, Francesco, Hur, Inyoung Wang, Vivian Abdi, Mesfin, Feng, Xin, Wood, Erin, Coleman, Simon, Firth, Paul, Barton, Alastair, Barolo, Massimiliano, Nagy, Zoltan K.
This paper introduces a comprehensive mathematical model of a novel integrated filter-dryer carousel system, designed for continuously filtering, washing and drying a slurry stream into a crystals cake. The simulator includes models for dead-end filtration, cake washing and convective cake...
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Identifying a Loss-in-Weight Feeder Design Space Based on Performance and Material Properties
09 Jun 2023 | Contributor(s):: Li, Tianyi, Scicolone, James V. Sanchez, Eric, Muzzio, Fernando J.
Powder properties, such as density and adhesion, can cause large variability in the flow rate of ingredients fed from feeders, which can propagate through the system. Knowing an ideal range of operation and correlating powder properties to process performance can result in faster optimization of...
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Development of drying-induced stresses in pharmaceutical granules prepared in continuous production line
09 Jun 2023 | Contributor(s):: Mezhericher, Maksim
The phenomenon of development of drying-induced stresses has been given a through consideration in the literature on drying of many products. At the same time, to the best of our knowledge, the open published sources contain no information on drying stresses in pharmaceutical granules prepared by...
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Determination of the kinetic parameters for the crystallization of paracetamol from water using metastable zone width experiments
09 Jun 2023 | Contributor(s):: Nagy, Zoltan K., Fujiwara, Mitsuko Woo, Xing Yi, Braatz, Richard D. ;
A new approach for the estimation of kinetic parameters of crystallization from data obtained during the determination of metastable zone width is presented. The method is based on a simplified dynamic model of the system, which combines the population balance and mass balance, as well as...
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Analytical Design and Operation of Systems with Crystallization, Filtration, and Recycling
09 Jun 2023 | Contributor(s):: Ward, Jeffrey D, Yu, Cheng-ching, Doherty, Michael F
In this article, we introduce an analogous dimensionless model for a continuous rotary drum filter and show that a similar methodology can be used to predict the behavior of a combined crystallizer and filter, and a reactor, crystallizer, filter, and recycle circuit. We show the effect of the...
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An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction
09 Jun 2023 | Contributor(s):: R Singh, M Ierapetritou, R Ramachandran
A novel manufacturing strategy based on continuous processing integrated with online monitoring tools coupled with efficient automatic feedback control system is highly desired for efficient Quality by Design (QbD) based manufacturing ofthe next generation of pharmaceutical products with optimal...
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A framework of hybrid model development with identification of plant-model mismatch
09 Jun 2023 | Contributor(s):: Chen, Yingjie, Ierapetritou, Marianthi
Abstract Hybrid modeling has attracted increasing attention in order to take advantage of the additional data to improve process understanding. Current practice often adopts mechanistic models to predict process behaviors. These mechanistic models are based on physical understandings and...