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  1. Multiple Organolithium Generation in the Continuous Flow Synthesis of Amitriptyline

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    10 May 2024 | Contributor(s):: Kupracz, Lukas, Kirschning, Andreas

    A continuous flow protocol for the preparation of the tricyclic antidepressant (TCA) amitriptyline is reported. The advantages of flow chemistry when handling organometallic agents as well as when performing reaction with gases are demonstrated. Continuous multilithiation combined with...