Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals
09 Jun 2023 | Contributor(s):: Sarma, B, Chen, JHsi, HY, Myerson, AS
Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and...
Nucleation kinetics of polymorphs: Induction period and interfacial energy measurements
09 Jun 2023 | Contributor(s):: Teychené, S., Biscans, B.
Nucleation kinetics of eflucimibe polymorphs have been investigated in ethanol and n-heptane mixture. The two eflucimibe polymorphs, A and B, crystallize concomitantly for a wide range of operating conditions. The effects of supersaturation on the nucleation rates of the two existing polymorphs...