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Qualitative Assessment of a Multi-Scale, Compartmental PBM-DEM Model of a Continuous Twin-Screw Wet Granulation Process
09 Jun 2023 | Contributor(s):: Barrasso, Dana, Ramachandran, Rohit
Wet granulation processes play a crucial role in solid oral dosage manufacturing processes. However, they are often designed empirically with poor efficiency. To implement quality-by-design, a more scientific understanding is desired to predict the effects of process and equipment design and...
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Population Balance Modeling to Predict Particle Size Distribution upon Scale-Up of a Combined Antisolvent and Cooling Crystallization of an Active Pharmaceutical Ingredient
09 Jun 2023 | Contributor(s):: Rosenbaum, Tamar, Tan, Li Dummeldinger, Michael Mitchell, Niall, Engstrom, Joshua
Herein, a population balance model (PBM) for a combined cooling and antisolvent crystallization process for an active pharmaceutical ingredient (API) has been developed and utilized to predict the product particle size distribution (PSD) for two sets of four ∼35 kg scale plant batches, with...
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Mathematical modeling and experimental validation of continuous slug-flow tubular crystallization with ultrasonication-induced nucleation and spatially varying temperature
09 Jun 2023 | Contributor(s):: Mozdzierz, Nicholas J., Lee, Yongkyu Hong, Moo Sun Benisch, Moritz H.P., Rasche, Michael L., Tropp, Uku Erik, Jiang, Mo, Myerson, Allan S., Braatz, Richard D.
Continuous slug-flow tubular crystallization has been explored by several Research Article groups in academia and industry as a way to produce crystals while having low capital equipment costs. In this crystallization type, slugs of slurry and gas consecutively travel through a tube, with a high...
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Fines removal in a continuous plug flow crystallizer by optimal spatial temperature profiles with controlled dissolution
09 Jun 2023 | Contributor(s):: Majumder, Aniruddha, Nagy, Zoltan K.
This work presents a systematic study for obtaining the optimal temperature profile in a continuous plug flow crystallizer (PFC). The proposed PFC consists of multiple segments where the temperature of each segment can be controlled individually. An optimization problem is formulated for a target...