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1. Process modelling and simulation for continuous pharmaceutical manufacturing of ibuprofen

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   09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI

   Pharmaceutical corporations face rapidly rising process Research Article and development (R&D) as well as production costs due to globalised competition. Batch production processes are dominant in the pharmaceutical industry and have multiple advantages, including equipment flexibility,...

2. Continuous manufacturing of pharmaceuticals

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   09 Jun 2023 | Contributor(s):: Johannes Khinast, Jukka Rantanen

   A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals.As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process...

3. A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

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   09 Jun 2023 | Contributor(s):: Martinetz, Michael Christian, Rehrl, Jakob Aigner, Isabella Sacher, Stephan, Khinast, Johannes

   Abstract In a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown...