Abstract In a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown of the tablet press. Various operating scenarios were simulated and the influence of turret speed on the tablet properties was experimentally investigated. Changes in the turret speed alter the critical process parameters dwell time and die filling time. Their influence was evaluated using two model formulations with different compaction behavior.

• Research Center Pharmaceutical Engineering GmbH
• Graz University of Technology

• Control

1. continuous manufacturing
2. Control
3. Discharge of material
4. Process simulation
5. Research Article
6. Rotary tablet press
7. Turret speed