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1. Monitoring blend potency in a tablet press feed frame using near infrared spectroscopy

   out of 5 stars 

   Contributor(s):: Ward, Howard, Blackwood, Daniel, Polizzi, Mark, Clarke, Hugh

   A near-infrared (NIR) probe was installed into the feed frame of a rotary tablet press to monitor API concentration as a function of time. A series of step change experimental trials were completed, where a placebo blend was initially charged into the feed frame, and an active blend was layered...

2. Development and validation of an in-line NIR spectroscopic method for continuous blend potency determination in the feed frame of a tablet press

   out of 5 stars 

   Contributor(s):: De Leersnyder, Fien, Peeters, Elisabeth, Djalabi, Hasna, Vanhoorne, Valérie, Van Snick, Bernd, Hong, Ke, Hammond, Stephen, Liu, Angela, Ziemons, Eric, Vervaet, Chris, De Beer, Thomas

   A calibration model for in-line API quantification based on near infrared (NIR) spectra collection during tableting in the tablet press feed frame was developed and validated. First, the measurement set-up was optimised and the effect of filling degree of the feed frame on the NIR spectra was...

3. A Continuous Operation Concept for a Rotary Tablet Press Using Mass Flow Operating Points

   out of 5 stars 

   Contributor(s):: Martinetz, Michael Christian, Rehrl, Jakob Aigner, Isabella Sacher, Stephan, Khinast, Johannes

   Abstract In a continuous pharmaceutical manufacturing line the rotary tablet press was viewed as the master of control concept and defined the mass flow through the entire process. According to a conventional control concept, missing mass flow from an upstream unit operation leads to a shutdown...