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1. Real-time feasible model-based crystal size and shape control of crystallization processes

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   09 Jun 2023 | Contributor(s):: Szilagyi, Botond, Nagy, Zoltan K.

   The simultaneous control of crystal size and shape is particularly important in fine chemical and pharmaceutical crystallization. These two quantities influence the dissolution rate and bioavailability of final drug products, and also contribute to the manufacturability and efficiency of...

2. Application of Continuous Crystallization in an Integrated Continuous Pharmaceutical Pilot Plant

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   09 Jun 2023 | Contributor(s):: Zhang, Haitao, Lakerveld, Richard, Heider, Patrick, Tao, Mengying, Su, Min, Testa, Christopher, D’Antonio, Alyssa, Barton, Paul, Braatz, Richard, Trout, Bernhardt, Myerson, Allan, Jensen, Klavs, Evans, James

   Real-time control using process analytical technology (PAT) tools is required for the implementation of continuous crystallization within integrated continuous manufacturing (ICM) of pharmaceuticals. However, appropriate selection of PAT tools is challenging, and the design and operation of...