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Tags: RTD

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  1. Development of a high-fidelity digital twin using the discrete element method for a continuous direct compression process. Part 2. Validation of calibration workflow

    Peer-reviewed journal | 30 Oct 2024 | Contributor(s):: Peter Toson, Marko Matić, Theresa Hörmann-Kincses, Michela Beretta, Jakob Rehrl, Johannes Poms, Peter Boehling, Thomas O’Connor, Abdollah Koolivand, Geng Tian, Scott M. Krull, Johannes G. Khinast, Johan Remmelgas, Dalibor Jajcevic

    This paper is the second in a series of two that describes the application of discrete element method (DEM) and reduced order modeling to predict the effect of disturbances in the concentration of drug substance at the inlet of a continuous powder mixer on the concentration of the drug...

  2. Continuous Manufacturing for Pharmaceutical Solid Dosage Forms (On-Demand)

    Seminars | 31 Jan 2024 | Contributor(s):: Atul Dubey, Fernando Muzzio, Gerardo Callegari, Lucy L. Botros, Ravendra Singh, James Scicolone, Andres Roman, Sonia Modarres Razavi

    Course Description: This self-paced curriculum contains fourteen self-paced modules and three recordings of live virtual education on Pharmaceutical Continuous Manufacturing (PCM). Learners will have access to the following: A recording of the introductory session covering topics such as...

  3. Continuous Manufacturing to Improve Pharmaceutical Quality: Research Examples and Opportunities

    Workshop | 20 Nov 2023 | Contributor(s):: Geng Tian

    Continuous manufacturing (CM) of drug substances and drug productsProcess modeling and simulation (M&S) for CM at FDACM research highlightsOpportunities of CM for generic drug productsPharmaceutical Quality Symposium 2023: Quality, Supply Chain & Advanced Manufacturing -...

  4. Residence Time Distribution (RTD)-Based Control System for Continuous Pharmaceutical Manufacturing Process

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Bhaskar, Aparajith, Singh, Ravendra

  5. Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Tanimura, Shinji, Singh, Ravendra Román-Ospino, Andrés D, Ierapetritou, Marianthi

    The presence of a ‘significant dead zone’ in any continuous manufacturing equipment may affect the product quality and need to be investigated systematically. Dead zone will affect the residence time distribution (RTD) of continuous manufacturing and thus the mixing and product quality. Tablet...