The Continuous-Flow Synthesis of Ibuprofen
Contributor(s):: Bogdan, Andrew R., Poe, Sarah L, Kubis, Daniel C., Broadwater, Steven J., McQuade, D. Tyler
Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.