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The Continuous-Flow Synthesis of Ibuprofen

By Bogdan, Andrew R.; Poe, Sarah L; Kubis, Daniel C.; Broadwater, Steven J.; McQuade, D. Tyler

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.

Journal

Angewandte Chemie International Edition. Volume 48, 2009, 8547-8550

DOI

10.1002/anie.200903055

Type of publication

Peer-reviewed journal

Affiliations

  • Cornell University
  • Florida State University

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. Byproducts
  3. continuous flow synthesis
  4. ibuprofen
  5. reagent
  6. Research Article
  7. simplified microreactor