The Continuous-Flow Synthesis of Ibuprofen

Bogdan, Andrew R.; Poe, Sarah L; Kubis, Daniel C.; Broadwater, Steven J.; McQuade, D. Tyler

The Continuous-Flow Synthesis of Ibuprofen

By Bogdan, Andrew R.; Poe, Sarah L; Kubis, Daniel C.; Broadwater, Steven J.; McQuade, D. Tyler

View Resource (DOI)

Published on CMKC

24 Apr 2024

Abstract

Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.

Journal

Angewandte Chemie International Edition. Volume 48, 2009, 8547-8550

DOI

10.1002/anie.200903055

Type of publication

Peer-reviewed journal

Affiliations

Cornell University
Florida State University

Article Classification

Research Article

Classification Areas

API