Optimization and sustainability assessment of a continuous flow Ru-catalyzed ester hydrogenation for an important precursor of a β2-adrenergic receptor agonist†
Contributor(s):: Prieschl, Michael, García-Lacuna, Jorge, Munday, Rachel, Leslie, Kevin, O'Kearney-McMullan, Anne, Hone, Christopher A., Kappe, C. Oliver
The development of a ruthenium-catalyzed continuous flow ester hydrogenation using hydrogen (H2) gas is reported. The reaction was utilized for the reduction of an important precursor in the synthesis of abediterol, a β2-adrenoceptor agonist that has undergone phase IIa clinical trials for the...