E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
| Contributor(s):: Stephen C. Born, Wei Wu, Khrystyna Shvedova, Ridade Sayin, Bhakti S. Halkude, Federica Casati, Anjana Ramnath, Paul Hermant, Bayan Takizawa, Thomas F. O'Connor, Xiaochuan Yang, Sukumar Ramanujamd, Salvatore Mascia, Christopher J. Testa, Chuntian Hu
Most drugs are still manufactured by time-intensive and cost-inefficient batch processes; however, the pharmaceutical industry is undergoing a transition to continuous processes to benefit from the reduced lead time, cost, and footprint and improved quality associated with this new methodology....
A Process for the Formation of Nanocrystals of Active Pharmaceutical Ingredients with Poor Aqueous Solubility in a Nanoporous Substrate
| Contributor(s):: O'Mahony, M, Leung, AKFerguson, S, Trout, BL, Myerson, AS
A potential process for the formation of nanocrystals of the poorly soluble drug, ibuprofen, within a nanoporous material is demonstrated. Nanocrystalline ibuprofen (IBP) is prepared at <= 106 nm by adding a solution containing IBP to particles of controlled pore glass (CPG) within a column so...