Resources (1-3 of 3)

1. New approach to optimizing risk management of the sticking problem using scale-independent critical material attributes and the quantitative process parameter

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   09 Jun 2023 | Contributor(s):: Ando, Hirotaka, Hara, Yuko, Sato, Kazunari, Dohi, Masafumi, Hakomori, Tadashi, Yonemochi, Etsuo

   In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of continuous operations. The aim of our study was...

2. Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting

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   09 Jun 2023 | Contributor(s):: Takeuchi, Y, Murase, YTahara, K, Takeuchi, H

   In the present study, surface-modified punches with different roughness were evaluated for their ability to prevent sticking during pharmaceutical tableting using a single punch machine. The surface roughness of the punch faces was assessed using a laser microscope. Acetaminophen and ibuprofen...

3. Direct compaction: An update of materials, trouble-shooting, and application

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   09 Jun 2023 | Contributor(s):: Li, Z, Zhao, LJLin, X, Shen, L, Feng, Y

   Direct compaction (DC) is the preferred choice for tablet manufacturing; however, only less than 20% of active pharmaceutical ingredients could be compacted via DC as its high requirement for functional properties of materials. Materials with improper functionalities could lead to serious...