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1. Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century

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   Contributor(s):: Tiwari, RV, Patil, H, Repka, MA

   Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic, rubber and food industry. HME has also emerged as an important technology for drug delivery applications in pharmaceutical Research Article and manufacturing because of its process automation and low-cost...

2. Continuous Melt Granulation for Taste-Masking of Ibuprofen

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   Contributor(s):: Forster, Seth P., Lebo, David B.

   This book covers key aspects of the continuous manufacturing of pharmaceuticals. The first part provides an overview of key chemical engineering principles and the current regulatory environment. The second covers existing technologies for manufacturing both small-molecule-based products and...

3. A review on the taste masking of bitter APIs: hot-melt extrusion (HME) evaluation

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   Contributor(s):: Maniruzzaman, M, Boateng, JSChowdhry, BZ, Snowden, MJ, Douroumis, D

   The majority of active pharmaceutical ingredients (APIs) found in oral dosage forms have a bitter taste. Masking the unpleasant taste of bitter, APIs is a major challenge in the development of such oral dosage forms. Taste assessment is an important quality-control parameter for evaluating...