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Manipulation of ionic liquid anion-solute-antisolvent interactions for the purification of acetaminophen

By Weber, CC; Kunov-Kruse, AJRogers, RD; Myerson, AS

View Resource (DOI)

Category

Peer-reviewed journal

Published on CMKC

Abstract

Hydrogen bond donating cosolvents have been shown to significantly reduce the solubility of acetaminophen (AAP) in ionic liquids containing the acetate anion. Reduced solubility arises from competition for solvation by the acetate anion and can be used for the design of advanced separation techniques, illustrated by the crystallization of AAP.

Journal

Chemical Communications. Volume 51, 2015, 4294-4297

DOI

10.1039/c5cc00198f

Type of publication

Peer-reviewed journal

Affiliations

  • Massachusetts Institute of Technology (MIT) (MIT)
  • University of Alabama

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. acetaminophen
  2. API
  3. Ionic liquids
  4. paracetamol
  5. Research Article