This chapter focuses on the application and development of unit operation and process models of the major routes of continuous solid dose manufacturing. Process models developed in the chapter are very important tools for the design of control system. The chapter also focuses on the current models available and their applications in process simulation and control systems. The chapter provides an introduction to process modeling in the pharmaceutical industry. The process flowsheet model has been used to understand the continuous tablet manufacturing process in order to design an efficient control system. The critical control variables of direct compaction continuous tablet manufacturing process have been identified based on process understanding and sensitivity analysis. The control system design, tuning, control hardware and software integration, and control system implementation into the pilot plant is demonstrated in detail via direct compaction continuous tablet manufacturing case study.

• Rutgers, The State University of New Jersey

• Oral doses
• Modeling

1. modeling
2. Oral doses
3. Review article