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Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

By Thomas, LH; Wales, C; Wilson, CC

Published on

Abstract

A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multicomponent environment. Previously unknown solvates have also been synthesised by this method.

Journal

Chemical Communications. Volume 52, 2016, 7372-7375

DOI

10.1039/c6cc01027j

Type of publication

Peer-reviewed journal

Affiliations

  • University of Bath
  • University of Glasgow

Article Classification

Research Article

Classification Areas

  • API

Tags