Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes
Category
Published on CMKC
Abstract
A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multicomponent environment. Previously unknown solvates have also been synthesised by this method.
Journal
Chemical Communications. Volume 52, 2016, 7372-7375
DOI
10.1039/c6cc01027j
Type of publication
Peer-reviewed journal
Affiliations
- University of Bath
- University of Glasgow
Article Classification
Research Article
Classification Areas
- API