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The route from problem to solution in multistep continuous flow synthesis of pharmaceutical compounds

By Bana, P; Orkenyi, RLovei, K; Lako, A; Turos, GI; Eles, J; Faigl, F; Greiner, I

Published on CMKC

Abstract

Recent advances in the field of continuous flow chemistry allow the multistep preparation of complex molecules such as APIs (Active Pharmaceutical Ingredients) in a telescoped manner. Numerous examples of laboratory-scale applications are described, which are pointing towards novel manufacturing processes of pharmaceutical compounds, in accordance with recent regulatory, economical and quality guidances. The chemical and technical knowledge gained during these studies is considerable; nevertheless, connecting several individual chemical transformations and the attached analytics and purification holds hidden traps. In this review, we summarize innovative solutions for these challenges, in order to benefit chemists aiming to exploit flow chemistry systems for the synthesis of biologically active molecules. (C) 2016 Elsevier Ltd. All rights reserved.

Journal

Bioorganic & Medicinal Chemistry. Volume 25, 2017, 6180-6189

DOI

10.1016/j.bmc.2016.12.046

Type of publication

Peer-reviewed journal

Affiliations

  • Budapest University of Technology and Economics
  • Gedeon Richter Plc
  • MTA BME Organ Chem Technol Res Grp

Article Classification

Research Article

Classification Areas

  • API

Tags