The scope of PAT in real-time advanced control of tablet quality
Category
Published on
Abstract
Continuous pharmaceutical manufacturing together with process analytical technology (PAT) provides a suitable platform for automatic feed-forward/feed-back (FF/FB) control of the end product quality as desired by quality by design (QbD)-based efficient manufacturing. The precise control of the quality of the pharmaceutical product requires proactive, corrective actions on the process/raw material variability. Therefore, PAT tools are necessary to monitor the FF as well as FB process variables that need to be sent to the automatic real-time control system. This article highlights the scope of PAT in a combined FF/FB control system of a continuous tablet manufacturing process.
Journal
European Pharmaceutical Review. Volume 20, 2015, 76-80
Type of publication
Peer-reviewed journal
Affiliations
- Rutgers, The State University of New Jersey
Article Classification
Opinion
Classification Areas
- Oral doses
- Modeling