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The scope of PAT in real-time advanced control of tablet quality
Contributor(s):: Singh, Ravendra, Ierapetritou, Marianthi, Ramachandran, Rohit
Continuous pharmaceutical manufacturing together with process analytical technology (PAT) provides a suitable platform for automatic feed-forward/feed-back (FF/FB) control of the end product quality as desired by quality by design (QbD)-based efficient manufacturing. The precise control of the...
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Process Analytical Tools for Flow Analysis: A Perspective
Contributor(s):: Price, Gregory A., Mallik, Debasis, Organ, Michael G
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Pharmaceutical Applications of Hot-Melt Extrusion: Continuous Manufacturing, Twin-Screw Granulations, and 3D Printing
Contributor(s):: Maniruzzaman , Mohammed
Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals. HME is an emerging processing technology used primarily for the manufacture of pharmaceutical solid dispersions. It also combines the advantages of a solvent-free process...
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Pharmaceutical formulation and manufacturing using particle/powder technology for personalized medicines
Contributor(s):: Tahara, Kohei
Particle/powder technology is used in the manufacture of many pharmaceutical products, and Research Article on the physical properties of particles in the nano- to micro-particle range is important in the pharmaceutical field. The concept of precision medicine will require an increasing shift in...
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Flowsheet Models Modernize Pharmaceutical Manufacturing Design and Risk Assessment
Contributor(s):: Muzzio, Fernando, Singh, M Sebastian Escotet-Espinoza Ravendra, Lee Sau, Thomas O’Connor Marianthi, Ierapetritou, Lee Sharmista Chatterjee Rohit Ramachandran, Sen, Maitraye
The pharmaceutical industry has recognized the value of implementing a systematic approach to drug product development where quality is built into the product and process. The FDA initiative on quality by design (QbD) promotes the design of the product and manufacturing process using principles...
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Designing a novel continuous manufacturing plant with superior monitoring and control
Contributor(s):: Singh, Ravendra, Zhang, Jun Ierapetritou, Marianthi, Ramachandran, Rohit
There is a growing interest in manufacturing the pharmaceutical product continuously . Along with other advantages , it provides an appropriate platform to implement suitable monitoring and control architecture, to improve the product quality and minimise product rejection and operating expenses....
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Breaking Through Barriers to Continuous Manufacturing
Contributor(s):: Markarian, Jennifer
Pharmaceutical manufacturing is inching towards implementing more efficient and sustainable processes, including continuous manufacturing (CM) of solid-dosage drugs. Advantages of CM include the potential for faster development, easier technical transfer, and more efficient and flexible...