Scale-Up of a Continuous Manufacturing Process of Edaravone
Category
Published on CMKC
Abstract
Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day and the purity of the final product is 99.95%, which are in accordance with the needs of production. This is an efficient and quick production process suitable for industrial production.
Journal
Organic Process Research & Development. Volume 25, 2021, 2146–2153
DOI
10.1021/acs.oprd.1c00228
Type of publication
Peer-reviewed journal
Affiliations
- Shenyang Pharmaceutical University
- General Hospital of Northern Theater Command
Article Classification
Research Article
Classification Areas
- API