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Scale-Up of a Continuous Manufacturing Process of Edaravone

By Zhou, Shuhao; Hong, Qingxia; Mei, Wenliu; He, Yan; Wu, Chengjun; Sun, Tiemin

View Resource (DOI)

Category

Peer-reviewed journal

Published on

Abstract

Edaravone belongs to a class of brain-protective agents, which can scavenge free radicals. To reduce impurities and improve the yield, a continuous flow production process of edaravone was developed. The synthesis is continuously carried out in two steps. The throughput can reach 11.328 kg/day and the purity of the final product is 99.95%, which are in accordance with the needs of production. This is an efficient and quick production process suitable for industrial production.

Journal

Organic Process Research & Development. Volume 25, 2021, 2146–2153

DOI

10.1021/acs.oprd.1c00228

Type of publication

Peer-reviewed journal

Affiliations

  • Shenyang Pharmaceutical University
  • General Hospital of Northern Theater Command

Article Classification

Research Article

Classification Areas

  • API

Tags

  1. API
  2. Edaravone
  3. free radical scavenger
  4. microreactors
  5. Research Article
  6. scale-up synthesis