In this chapter, the main processing steps and manufacturing aspects of solid dosage forms are described and the relevant literature is reviewed. Starting with powder feeding, powder blending, granulation (dry and wet), and drying the most important unit operations to make compactable granules are reviewed. As an alternative to granulation, hot-melt extrusion is introduced, together with the various downstream processing choices. Next, tableting and capsule filling-for making a final dosage form-are discussed, followed by a section on coating. In all sections scale-up methods are reviewed and an outlook for future developments is provided. The last two sections are devoted to process analytical technology (PAT) and continuous manufacturing.

• Research Center Pharmaceutical Engineering GmbH (RCPE)

• Oral solid dose

1. continuous manufacturing
2. oral solid dose
3. Particle processing
4. Pharmaceutical Manufacturing
5. Process analytical technology
6. Research Article