Utility of continuous flow chemistry in a carboxylation reaction and palladium-mediated α-arylation reaction is described. A two-step carboxylation reaction of an aryl group involving an anion formation, followed by quench with gaseous carbon dioxide was developed on small scale using HDPE tubes in a dry ice/acetone bath. The process was then scaled up using stainless steel tubes of larger diameter and static mixers to process 22 kg of material in a regular lab in 88% yield. Similarly, a continuous flow process for a hazardous palladium-mediated α-arylation reaction which had a significant exotherm during heat up was developed.

• Albany Molecular Research Inc.

• Intermediate

1. α-Arylation
2. Book chapter
3. carboxylation
4. exotherm 
5. Intermediate
6. palladium
7. Scale-up