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Application of the quantitative detection of a change in concentration of magnesium stearate in a feeder tube of tableting manufacture by real-time near-infrared spectroscopy

By Sasakura, D.; Nakayama, K.; Chikuma, T.

Published on CMKC

Abstract

Process analytical technology is important for the analysis and control of manufacturing processes. Near-infrared spectroscopy is widely used in various process analytical technologies for the analysis of the chemical components of solid dosage forms. Lubrication is an important process carried out before a tablet is produced. In this process, the concentration of lubricant, such as magnesium stearate (StMg), might change for one of many reasons during powder transport, which would be a critical problem such as variation in tablet compressibility and dissolution failure of compressed tablets. Our group investigated the feasibility of the quantitative monitoring of a change in the concentration of StMg in the feeder tube of tableting equipment employing real-time near-infrared spectroscopy.

Journal

Pharmazie. Volume 70, 10, 2015, 636-639

DOI

10.1691/ph.2015.4219

Type of publication

Peer-reviewed journal

Affiliations

  • Showa Pharmaceutical University

Article Classification

Research article

Classification Areas

  • PAT
  • Oral solid dose
  •  

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