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Hot melt extrusion technology for continuous manufacturing

By Furqan Tahir; Lovett. David

Published on CMKC

Abstract

Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage formulations, including solid dose form, which is of particular importance for poorly soluble APIs.¹ Other advantages of HME technology include the ability to incorporate inline process analytical technology (PAT) - enabling a quality by design (QbD) approach to continuous manufacturing - and the capacity to process a wide range of excipients, many of which cannot be processed using established manufacturing techniques.

Journal

European Pharmaceutical Review. Volume 22, 2017, 36-39

Type of publication

Peer-reviewed journal

Affiliations

  • Perceptive Engineering

Article Classification

Research article

Classification Areas

  • PAT
  • Oral solid dose

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