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Pharmaceutical Applications of Hot-Melt Extrusion: Continuous Manufacturing, Twin-Screw Granulations, and 3D Printing
Contributor(s):: Maniruzzaman , Mohammed
Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals. HME is an emerging processing technology used primarily for the manufacture of pharmaceutical solid dispersions. It also combines the advantages of a solvent-free process...
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Hypromellose - A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery
Contributor(s):: Maskova, Eliska, Kubova, Katerina, Raimi-Abraham, Bahijja T., Vllasaliu, Driton, Vohlidalova, Eva, Turanek, Jaroslav, Masek, Josef
Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great...
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Hot melt extrusion technology for continuous manufacturing
Contributor(s):: Furqan Tahir, Lovett. David
Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage...
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Development of immediate release 3D-printed dosage forms for a poorly water-soluble drug by fused deposition modeling: Study of morphology, solid state and dissolution
Contributor(s):: Fanous, M, Bitar, MGold, S, Sobczuk, A, Hirsch, S, Ogorka, J, Imanidis, G
3D-printing technologies such as Fused Deposition Modeling (FDM) bring a unique opportunity for personalized and flexible near-patient production of pharmaceuticals, potentially improving safety and efficacy for some medications. However, FDM-printed tablets often exhibit tendency for slow...
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Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins
Contributor(s):: Bloomquist, CJ, Mecham, MBParadzinsky, MD, Janusziewicz, R, Warner, SB, Luft, JC, Mecham, SJ, Wang, AZ, DeSimone, JM
Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to...
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Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century
Contributor(s):: Tiwari, RV, Patil, H, Repka, MA
Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic, rubber and food industry. HME has also emerged as an important technology for drug delivery applications in pharmaceutical Research Article and manufacturing because of its process automation and low-cost...
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3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow
Contributor(s):: Maier, MC, Valotta, AHiebler, K, Soritz, S, Gavric, K, Grabner, B, Gruber-Woelfler, H
Advances in flow chemistry to produce active pharmaceutical ingredients (APIs) require performing reactions in tailor-made equipment as complexity of the planned setups increases. To react quickly and with low costs to these demanding reactions, additive manufacturing, also known as 3D printing,...
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3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries
Contributor(s):: Sagandira, CR, Siyawamwaya, M, Watts, P
The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredients and embracing enabling technologies. Both 3D...