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Tags: 3D printing

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  1. Advanced Manufacturing: An answer to supply chain woes?

    Magazine | 18 Jul 2024 | Contributor(s):: Atul Dubey

    Advanced Manufacturing technologies (AMTs) in the pharmaceutical industry have increasingly gained attention in the last decade. Amongst the AMTs, continuous manufacturing (CM) has had the most prominent impact so far. International efforts to define manufacturing approaches, terms, regulatory...

  2. Pharmaceutical Applications of Hot-Melt Extrusion: Continuous Manufacturing, Twin-Screw Granulations, and 3D Printing

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Maniruzzaman , Mohammed

    Recently, hot-melt extrusion (HME) techniques have been presented as innovative platforms to produce various pharmaceuticals. HME is an emerging processing technology used primarily for the manufacture of pharmaceutical solid dispersions. It also combines the advantages of a solvent-free process...

  3. Hypromellose - A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Maskova, Eliska, Kubova, Katerina, Raimi-Abraham, Bahijja T., Vllasaliu, Driton, Vohlidalova, Eva, Turanek, Jaroslav, Masek, Josef

    Hydroxypropylmethylcellulose (HPMC), also known as Hypromellose, is a traditional pharmaceutical excipient widely exploited in oral sustained drug release matrix systems. The choice of numerous viscosity grades and molecular weights available from different manufacturers provides a great...

  4. Hot melt extrusion technology for continuous manufacturing

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Furqan Tahir, Lovett. David

    Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage...

  5. Enabling intensification of multiphase chemical processes with additive manufacturing

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: McMillin, RE, Luxon, AR, Ferri, JK

    Fixed bed supports of various materials (metal, ceramic, polymer) and geometries are used to enhance the performance of many unit operations in chemical processes. Consider first metal and ceramic monolith support structures, which are typically extruded. Extruded monoliths contain regular,...

  6. Development of immediate release 3D-printed dosage forms for a poorly water-soluble drug by fused deposition modeling: Study of morphology, solid state and dissolution

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Fanous, M, Bitar, MGold, S, Sobczuk, A, Hirsch, S, Ogorka, J, Imanidis, G

    3D-printing technologies such as Fused Deposition Modeling (FDM) bring a unique opportunity for personalized and flexible near-patient production of pharmaceuticals, potentially improving safety and efficacy for some medications. However, FDM-printed tablets often exhibit tendency for slow...

  7. Controlling release from 3D printed medical devices using CLIP and drug-loaded liquid resins

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Bloomquist, CJ, Mecham, MBParadzinsky, MD, Janusziewicz, R, Warner, SB, Luft, JC, Mecham, SJ, Wang, AZ, DeSimone, JM

    Mass customization along with the ability to generate designs using medical imaging data makes 3D printing an attractive method for the fabrication of patient-tailored drug and medical devices. Herein we describe the application of Continuous Liquid Interface Production (CLIP) as a method to...

  8. Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Bandari, Suresh, Nyavanandi, Dinesha, Dumpa, Nagireddy, Repka, Michael A.

    Interest in 3D printing for pharmaceutical applications has increased in recent years. Compared to other 3D printing techniques, hot melt extrusion (HME)-based fused deposition modeling (FDM) 3D printing has been the most extensively investigated for patient-focused dosage. HME technology can be...

  9. Contribution of hot-melt extrusion technology to advance drug delivery in the 21st century

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Tiwari, RV, Patil, H, Repka, MA

    Introduction: Hot-melt extrusion (HME) technology is applied successfully in the plastic, rubber and food industry. HME has also emerged as an important technology for drug delivery applications in pharmaceutical Research Article and manufacturing because of its process automation and low-cost...

  10. A comprehensive overview of extended release oral dosage forms manufactured through hot melt extrusion and its combination with 3D printing

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Nashed, Nour, Lam, Matthew, Nokhodchi, Ali

    Oral dosage formulations are considered to be the most convenient pharmaceutical dosage forms for almost all ages because of their simplicity and non-invasive administration compared to other dosage forms. To improve therapeutic efficacy and avoid frequent daily doses, extending drug release...

  11. 3D Printed Reactors for Synthesis of Active Pharmaceutical Ingredients in Continuous Flow

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Maier, MC, Valotta, AHiebler, K, Soritz, S, Gavric, K, Grabner, B, Gruber-Woelfler, H

    Advances in flow chemistry to produce active pharmaceutical ingredients (APIs) require performing reactions in tailor-made equipment as complexity of the planned setups increases. To react quickly and with low costs to these demanding reactions, additive manufacturing, also known as 3D printing,...

  12. 3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries

    Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sagandira, CR, Siyawamwaya, M, Watts, P

    The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ingredients and embracing enabling technologies. Both 3D...