Hot melt extrusion (HME), a manufacturing technique traditionally used in the plastic and food industries, is now attracting significant interest from the pharmaceutical manufacturing sector. This is primarily because HME enables the continuous manufacture of a wide variety of dosage formulations, including solid dose form, which is of particular importance for poorly soluble APIs.¹ Other advantages of HME technology include the ability to incorporate inline process analytical technology (PAT) - enabling a quality by design (QbD) approach to continuous manufacturing - and the capacity to process a wide range of excipients, many of which cannot be processed using established manufacturing techniques.

• Perceptive Engineering

• PAT
• Oral solid dose

1. 3D printing
2. manufacturing
3. oral solid dose
4. pat
5. Polymers
6. Process analytical technology (PAT)
7. Research Article