We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modem healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental Research Article endeavor. This part details the syntheses of bioactive natural products and commercial drugs.

• Federal University of Sao Carlos (UFSCar)
• Universidade Estadual de Campinas (UNICAMP)
• Federal University of Rio de Janeiro (UFRJ)

• API

1. API
2. APIs
3. continuous flow
4. natural products
5. Research Article
6. synthesis