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  1. Continuous Manufacturing: Many Want It, But Here's Why Few Have It

    Website | Contributor(s): Ioanna Deni

    Continuous manufacturing remains a key objective among bioprocessing professionals. While continuous bioprocessing isn’t a new concept, having been applied in the production of both old and new products, significant technological advancements set the stage for its wider adoption.

  2. Influence of refilling on dosing accuracy of loss-in-weight powder feeders in continuous manufacturing

    Peer-reviewed journal | Contributor(s): Jochen Thies, Peter Kleinebudde, Fabiola N. Santamaría Alvarez

    Continuous manufacturing is a novel concept to produce high quality drug products. The manufacture of solid dosage forms starts with the feeding of materials, which is consider a critical step because it could have a high influence on the quality of the final product. Therefore, this unit...

  3. Compact NMR Spectroscopy for Automated Continuous-Flow Production of Chemicals and Pharmaceuticals (On-Demand)

    Seminars | Contributor(s): Klas Meyer

    Chemical companies are under constant pressure to improve productivity while cutting costs. Flexible and modular chemical plants can produce high-quality products using multi-purpose equipment with short downtimes, reducing time to market for new products. Intensified continuous production...

  4. Continuous Manufacturing for Pharmaceutical Solid Dosage Forms (On-Demand)

    Seminars | Contributor(s): Atul Dubey, Fernando Muzzio, Gerardo Callegari, Lucy L. Botros, Ravendra Singh, James Scicolone, Andres Roman, Sonia Modarres Razavi

    Course Description: This self-paced curriculum contains fourteen self-paced modules and three recordings of live virtual education on Pharmaceutical Continuous Manufacturing (PCM). Learners will have access to the following: A recording of the introductory session covering topics such as...

  5. USP Excipients Workshop: Understanding the Impact of Material Attributes on Product Quality for Continuous Manufacturing (On-Demand)

    Seminars | Contributor(s): Thomas O’Connor

    For continuous manufacturing processes, the impact of variation in material attributes on material feeding and process dynamics should be characterized and appropriate controls implemented if needed.

  6. Advancing tablet lubrication: A systematic comparison of feed frame lubrication and internal lubrication

    Peer-reviewed journal | Contributor(s): Jens Bartsch, Markus Thommes, Christopher Mathias, René Brands

    For the continuous manufacturing of tablets, internal lubrication is often utilized. Here, lubricant is added to a pre-blend in an additional blending step. However, over-lubrication may occur, with a negative impact on the tablet quality. This study consequently focuses on the...

  7. Five key factors to consider when selecting a granulation system for tablet manufacturing

    Magazine | Contributor(s): Fi Forrest

    Granulation is a vital process in pharmaceutical dosage forms, transforming powders into granules. Michael Schupp from Gerteis - specialists in dry granulation systems for the pharmaceutical industry - discusses what you should be looking for when choosing your granulation method. 

  8. New gravimetric dosing device for Continuous Manufacturing

    Website | Contributor(s): VX management

    "So far, it is mainly Loss in Weight feeders (LIW) that are used for this purpose, especially in the pharmaceutical industry, as they can handle smaller flow rates accurately enough. The mechanical concept of these is decades old and despite miniaturisation and improvements at detail...

  9. Liquid API feeding in pharmaceutical HME: Novel options in solid dosage manufacturing

    Peer-reviewed journal | Contributor(s): Simone Eder, Aygün Doğan, Johannes Khinast, Stephan Sacher, Martin Spoerk, Lisa Kuchler

    Hot melt extrusion (HME) is a common unit operation. It is broadly applicable in the pharmaceutical industry and can be implemented in a continuous manufacturing line. However, the conventional way of active pharmaceutical ingredient (API) feeding with a pre-blend consisting of a powdered API...

  10. USP-ID

    Website | Contributor(s): Molly Ferns

    USP-ID, delivered by Mestrelab Research, is a one-click, automated software solution for identifying, quantifying and labelling a broad range of chemical components in both simple solutions and complex mixtures by qNMR.

  11. Quality & Regulatory Solutions for PAT in Continuous Manufacturing

    Magazine | Contributor(s): Gabriella Dahlgren, Kevin A. Macias, Antonio R. Moreira, Duncan R. Thompson, Christoph Herwig, Robert Dream

    Process analytical technology (PAT) is perceived as the main enabler for a robust control strategy with continuous manufacturing (CM) because process analytical technology can aid in implementing continuous manufacturing throughout the entire life cycle. This article discusses quality and...

  12. Batch vs. continuous direct compression – a comparison of material processability and final tablet quality

    Peer-reviewed journal | Contributor(s): S. Fathollahi, D. Vanderroost, T. Roelofs, B.H.J. Dickhoff, C. Vervaet, V. Vanhoorne, B. Bekaert, P.H.M. Janssen

    In this study, an in-depth comparison was made between batch and continuous direct compression using similar compression set-ups. The overall material processability and final tablet quality were compared and evaluated. Correlations between material properties, process parameters and final...

  13. E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals

    Peer-reviewed journal | Contributor(s): Stephen C. Born, Wei Wu, Khrystyna Shvedova, Ridade Sayin, Bhakti S. Halkude, Federica Casati, Anjana Ramnath, Paul Hermant, Bayan Takizawa, Thomas F. O'Connor, Xiaochuan Yang, Sukumar Ramanujamd, Salvatore Mascia, Christopher J. Testa, Chuntian Hu

    Most drugs are still manufactured by time-intensive and cost-inefficient batch processes; however, the pharmaceutical industry is undergoing a transition to continuous processes to benefit from the reduced lead time, cost, and footprint and improved quality associated with this new methodology....

  14. Sustainability case studies on the use of continuous manufacturing in pharmaceutical production

    Peer-reviewed journal | Contributor(s): Mark S. Kerr, Kevin P. Cole

    Continuous processing is now commonly used in the manufacturing of fine chemicals including agrochemicals and pharmaceuticals. Datasets are now available, including some on environmental sustainability aspects, that enable more direct comparison between related batch and flow processes....

  15. MOOC 1 Introduction to Continuous Manufacturing

    Teaching Materials | Contributor(s): RCPE

  16. Residence Time Distribution - Test Example

    Teaching Materials | Contributor(s): RCPE

  17. MOOC I - Batch vs. Continuous Manufacturing: Revolutionizing Medicine Production

    Teaching Materials | Contributor(s): RCPE

  18. MOOC I Introduction - The Advantages and Challenges of Continuous Manufacturing in Pharmaceuticals

    Teaching Materials | Contributor(s): RCPE

    In this video, we start exploring the world of continuous manufacturing in the pharmaceutical industry. Discover how this innovative technology is revolutionizing the production of medicines, its advantages over traditional batch manufacturing, and the challenges it presents. Join us as we delve...

  19. MOOC I Blending - Flow and Mixing Regime

    Teaching Materials | Contributor(s): RCPE

  20. MOOC I Feeding - Refill Strategy

    Teaching Materials | Contributor(s): RCPE

  21. MOOC I Blending Basics

    Teaching Materials | Contributor(s): RCPE

  22. MOOC I Continuous Blender Types

    Teaching Materials | Contributor(s): RCPE

  23. MOOC I Feeding - Twin Screw Feeder

    Teaching Materials | Contributor(s): RCPE

  24. MOOC I Feeding - Disturbances

    Teaching Materials | Contributor(s): RCPE

  25. MOOC I Continuous Blend Analysis

    Teaching Materials | Contributor(s): RCPE