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E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
Peer-reviewed journal | 06 Dec 2023 | Contributor(s):: Stephen C. Born, Wei Wu, Khrystyna Shvedova, Ridade Sayin, Bhakti S. Halkude, Federica Casati, Anjana Ramnath, Paul Hermant, Bayan Takizawa, Thomas F. O'Connor, Xiaochuan Yang, Sukumar Ramanujamd, Salvatore Mascia, Christopher J. Testa, Chuntian Hu
Most drugs are still manufactured by time-intensive and cost-inefficient batch processes; however, the pharmaceutical industry is undergoing a transition to continuous processes to benefit from the reduced lead time, cost, and footprint and improved quality associated with this new methodology....
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Towards a Greener Pharmacy by More Eco Design
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Baron, M
This review proposes an overview of the main trends explored by the pharmaceutical industry in order to develop a greener and smarter pharmacy minimizing any negative impact to the environment, and using more sustainable processes and drugs. If many drugs have their origin in nature, many active...
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A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Baumann, M, Moody, TSSmyth, M, Wharry, S
Continuous flow manufacture is an innovative technology platform, which is gaining momentum within the pharmaceutical industry. The key advantages of continuous flow include faster and safer reactions, which can be more environmentally friendly, smaller footprint, better quality product, and...