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A Three-Minute Synthesis and Purification of Ibuprofen: Pushing the Limits of Continuous-Flow Processing
10 May 2024 | Contributor(s):: Snead, David R., Jamison, Timothy F.
In a total residence time of three minutes, ibuprofen was assembled from its elementary building blocks with an average yield of above 90 % for each step. A scale-up of this five-stage process (3 bond-forming steps, one work-up, and one in-line liquid–liquid separation) provided ibuprofen at a...
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The Continuous-Flow Synthesis of Ibuprofen
24 Apr 2024 | Contributor(s):: Bogdan, Andrew R., Poe, Sarah L, Kubis, Daniel C., Broadwater, Steven J., McQuade, D. Tyler
Let relief flow forth! A three-step, continuous-flow synthesis of ibuprofen was accomplished using a simplified microreactor. By designing a synthesis in which excess reagents and byproducts are compatible with downstream reactions, no intermediate purification or isolation steps are required.
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Technoeconomic Optimization of a Conceptual Flowsheet for Continuous Separation of an Analgaesic Active Pharmaceutical Ingredient (API)
09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI
Continuous Pharmaceutical Manufacturing (CPM) has recently emerged as a promising alternative to current batch production methods, which require significant expenditures in order to ensure product quality and process reliability. Advances in new continuous synthesis routes, demonstrations of full...
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Process Modeling Issues in the Design of a Continuous-Flow Process for the Production of Ibuprofen
09 Jun 2023 | Contributor(s):: Tripodi, A, Martinazzo, RRamis, G, Rossetti, I
The continuous-flow production of active pharmaceutical ingredients is a spreading applicative Research Article field. Process simulation tools are effective means for in silico process design, but care is needed. A paradigmatic example is the synthesis of ibuprofen. First, the most appropriate...
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Process modelling and simulation for continuous pharmaceutical manufacturing of ibuprofen
09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI
Pharmaceutical corporations face rapidly rising process Research Article and development (R&D) as well as production costs due to globalised competition. Batch production processes are dominant in the pharmaceutical industry and have multiple advantages, including equipment flexibility,...
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Plantwide design and economic evaluation of two Continuous Pharmaceutical Manufacturing (CPM) cases: Ibuprofen and artemisinin
09 Jun 2023 | Contributor(s):: Jolliffe, HG, Gerogiorgis, DI
Increasing Research Article and Development (R&D) costs, growing competition from generic manufacturers and dwindling market introduction rates for novel drug products bolster the efforts of pharmaceutical firms to secure competitiveness by investigating Continuous Pharmaceutical Manufacturing...
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Low Energy Nanoemulsions as Templates for the Formulation of Hydrophobic Drugs
09 Jun 2023 | Contributor(s):: Badruddoza, AM, Gupta, AMyerson, AS, Trout, BL, Doyle, PS
Most small molecule active pharmaceutical ingredients (APIs) are hydrophobic which poses formulation challenges due to their poor water solubility. Current approaches are energy intensive and involve presenting the API in a nanoparticle form that is then combined with other additives into a...
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Impact of surface roughness of pre-treated punches and powder properties on prevention of sticking during pharmaceutical tableting
09 Jun 2023 | Contributor(s):: Takeuchi, Y, Murase, YTahara, K, Takeuchi, H
In the present study, surface-modified punches with different roughness were evaluated for their ability to prevent sticking during pharmaceutical tableting using a single punch machine. The surface roughness of the punch faces was assessed using a laser microscope. Acetaminophen and ibuprofen...
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Dynamic Plantwide Modeling, Uncertainty, and Sensitivity Analysis of a Pharmaceutical Upstream Synthesis: Ibuprofen Case Study
09 Jun 2023 | Contributor(s):: Montes, Frederico C.C., Gernaey, Krist, Sin, Gürkan
A dynamic plantwide model was developed for the synthesis of the active pharmaceutical ingredient (API) ibuprofen, following the Hoescht synthesis process. The kinetic parameters, reagents, products, and byproducts of the different reactions were adapted from literature, and the different process...