All Categories (1-2 of 2)

1. Catalytic Static Mixers for the Continuous Flow Hydrogenation of a Key Intermediate of Linezolid (Zyvox)

   0.0 out of 5 stars 

   25 Jun 2024 | Contributor(s):: Gardiner, James, Nguyen, Xuan, Genet, Charlotte, Horne, Mike D., Hornung, Christian H., Tsanaktsidis, John

   Catalytic static mixers (CSMs) were used for the efficient preparation of a key intermediate of the antimicrobial drug linezolid (Zyvox). The approach combines 3D printing and additive manufacturing techniques with continuous flow processing to produce a general method for catalytic...

2. Seven-Step Continuous Flow Synthesis of Linezolid Without Intermediate Purification

   0.0 out of 5 stars 

   24 Apr 2024 | Contributor(s):: Russel, M. Grace, Jamison, Timothy F.

   Herein, the blockbuster antibacterial drug linezolid is synthesized from simple starting blocks by a convergent continuous flow sequence involving seven (7) chemical transformations. This is the highest total number of distinct reaction steps ever performed in continuous flow without conducting...