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Twin Screw Continuous Wet Granulation
Contributor(s):: Shah, Ankita V., Serajuddin, Abu T. M.
Granulation has become an integral part of the formulation of tablets. Wet granulation and roller compaction, which were developed over 50 years ago in the 1950s and 1960s, are still the most commonly used granulation methods in the pharmaceutical industry. However, these are batch processes and...
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Near-Infrared Spectroscopy as Process Analytical Technology in Continuous Solid Dosage Form Manufacturing
Contributor(s):: Peeters, M., De Beer, T., Narang, Ajit S., Dubey, Atul., Kumar, A
In this chapter titled “Near-infrared Spectroscopy as Process Analytical Technology in Continuous Solid Dosage Form Manufacturing” the fundamentals of near-infrared spectroscopy (NIRS) and the mainstream and emerging NIRS analyzer technologies for process analytical technology (PAT) applications...
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Introduction to the Theory and Practice of Sampling
Contributor(s):: Esbensen, Kim H
Sampling is an important, but sometimes hidden, part of everyday life in science, technology, industry, society and commerce where decisions are made based on analytical results, which must be based on reliable samples. However, there is a very long and complex pathway from heterogeneous...
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How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems
Contributor(s):: Sarang Oka, Muzzio, Fernando
How to Design and Implement Powder-to-Tablet Continuous Manufacturing Systems provides a comprehensive overview on the considerations necessary for the design of continuous pharmaceutical manufacturing processes. The book covers both the theory and design of continuous processing of associated...
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Continuous Pharmaceutical Processing
Contributor(s):: Zoltan K Nagy, Arwa El Hagrasy, Jim Litster
Covers chemical engineering principles, regulatory aspects, primary and secondary manufacturing, process analytical technology and quality-by-design
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Continuous manufacturing of pharmaceuticals
Contributor(s):: Johannes Khinast, Jukka Rantanen
A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals.As rising costs outpace new drug development, the pharmaceutical industry has come under intense pressure to improve the efficiency of its manufacturing processes. Continuous process...
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Characterization of material properties
Contributor(s):: Razavi, Sonia, Oka, Sarang, Escotet-Espinoza, M. Sebastian, Wang, Yifan, Li, Tianyi, Futran Mauricio., Muzzio, Fernando
This chapter describes the importance of deepening our understanding of material properties and their effect on process performance. There are many measurement techniques to describe the complex nature of powders, some of which are provided in this chapter. Strong knowledge of multivariate...
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Cellulose Ethers for Extrusion Applications
Contributor(s):: Pinto, Elanor, Duerig, Thomas
Cellulose ethers have been used for years in developing oral dosage forms via batch processes such as direct compression and wet granulation. Recent advances in continuous manufacturing have brought about innovative technologies such as hot melt extrusion, melt extrusion granulation, and...
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An Overview of Pharmaceutical Manufacturing for Solid Dosage Forms
Contributor(s):: Sacher, Stephan, Khinast, Johannes G.
In this chapter, the main processing steps and manufacturing aspects of solid dosage forms are described and the relevant literature is reviewed. Starting with powder feeding, powder blending, granulation (dry and wet), and drying the most important unit operations to make compactable granules...
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A Framework for Representative Sampling for NIR Analysis – Theory of Sampling (TOS)
Contributor(s):: Esbensen, Kim H, Ciurczak, Emil W., Igne, Benoît, Workman, Jr.,Jerome, Burns, Donald A., Romañach, Rodolfo J.
This chapter deals with all critical steps before near-infrared spectroscopy (NIR) analysis, irrespective of whether the total sampling error contribution is large, intermediate, or small – all cases can be treated identically, including the widespread sensor-based solutions from the...