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The role of digital twins in driving sustainability
Peer-reviewed journal | 29 Oct 2024 | Contributor(s):: Deborah McElhone, Barrie Cassey, Kamal Abu-Hassan
As the pharmaceutical sector endeavours to become more sustainable, we hear how digital twins – virtual replicas of systems or products that can help predict performance – are supporting the industry in its efforts.
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A modeling and control framework for extraction processes
Peer-reviewed journal | 05 Sep 2024 | Contributor(s):: Peter Neugebauer, Jakob Rehrl, Peter Poechlauer, Dirk Kirschneck, Martin Horn, Martin Steinberger, Stephan Sacher, Joscha Boehm, Daniel Moser
Many continuously operated pharmaceutical process routes have been presented recently. Most of these cover the synthesis of the active pharmaceutical ingredient (API) or solid dosage processing. However, the API purification is also gaining attraction. One widespread and waste-intensive unit...
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The Rise of Continuous Manufacturing in Pharma
Website | 13 Aug 2024 | Contributor(s):: Editorial Team
"Mr Indu Bhushan, CEO and Director of STEERLife shares his insights on the transformative journey of continuous manufacturing, and the advanced technologies that have propelled this paradigm shift. He also throws light on how continuous manufacturing has accelerated drug development...
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Continuous Manufacturing in the Pharmaceutical Industry: Enhancing Drug Production
Website | 23 Jul 2024 | Contributor(s):: Timmerman, Siebe
A significant shift towards continuous manufacturing (CM) is currently underway in the pharmaceutical industry. Unlike the more commonly used batch processing, CM operates continuously. This method potentially offers increased efficiency, agility, and flexibility in the manufacturing of drug...
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Process Intensification via End-to-End Continuous Manufacturing of Atorvastatin Calcium Using an Integrated, Modular Reaction-Crystallization-Spherical Agglomeration-Filtration-Drying Process
Peer-reviewed journal | 23 Jul 2024 | Contributor(s):: Parvaresh, Rojan, Nagy, Zoltan K.
Continuous manufacturing can show potential benefits over batch processing in lower turnaround times and smaller footprint in addition to higher productivity, adaptability, and consistent product quality. Although these possible benefits exist, there are also challenges in integrating the various...
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Development and Application of Control Concepts for Twin-Screw Wet Granulation in the ConsiGmaTM-25: Part 2 Granule Size
Peer-reviewed journal | 04 Jun 2024 | Contributor(s):: Selma Celikovic, Johannes Poms, Johannes Khinast, Martin Horn, Jakob Rehrl
Traditional operation modes, such as running the production processes at constant process settings or within a narrow design space, do not fully exploit the advantages of continuous pharmaceutical manufacturing. Integrating Quality by Control (QbC) algorithms as a standard component of...
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Compact NMR Spectroscopy for Automated Continuous-Flow Production of Chemicals and Pharmaceuticals (On-Demand)
Seminars | 31 Jan 2024 | Contributor(s):: Klas Meyer
Chemical companies are under constant pressure to improve productivity while cutting costs. Flexible and modular chemical plants can produce high-quality products using multi-purpose equipment with short downtimes, reducing time to market for new products. Intensified continuous production...
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MOOC I Control Strategy - Process Control
Teaching Materials | 29 Nov 2023 | Contributor(s):: RCPE
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MOOC I Control Strategy - Examples
Teaching Materials | 29 Nov 2023 | Contributor(s):: RCPE
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MOOC I Control Strategy - Introduction
Teaching Materials | 29 Nov 2023 | Contributor(s):: RCPE
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MOOC I Control Strategy - Quality Control
Teaching Materials | 29 Nov 2023 | Contributor(s):: RCPE
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Videometric mass flow control: A new method for real-time measurement and feedback control of powder micro-feeding based on image analysis
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Madarasz, L, Kote, AGyurkes, M, Farkas, A, Hambalko, B, Pataki, H, Fulop, G, Marosi, G, Lengyel, L, Casian, T, Csorba, K, Nagy, ZK
The present paper reports the first monitoring and control of ultra-low dose powder feeding using a camera image-based mass flow measurement system. Caffeine was fed via a single-screw microfeeder as a model active pharmaceutical ingredient (API). The mass, mass flow and sizes of the particles...
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Why We Need Continuous Pharmaceutical Manufacturing and How to Make It Happen
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Clive Badman, Charles L.Cooney, Alastair Florence, Konstantin Konstantinov, Markus Krumme, Salvatore Mascia, Moheb Nasr, Bernhardt L. Trout
We make the case for why continuous pharmaceutical manufacturing is essential, what the barriers are, and how to overcome them. To overcome them, government action is needed in terms of tax incentives or regulatory incentives that affect time.
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The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Monteyne, Tinne, Heeze, Liza, Mortier, Severine Therese F. C., Oldorp, Klaus, Nopens, Ingmar, Remon, Jean-Paul, Vervaet, Chris, De Beer, Thomas
Twin-screw hot melt granulation (TS HMG) is a valuable, but still unexplored alternative to granulate temperature and moisture sensitive drugs in a continuous way. Recently, the material behavior of an immiscible drug-binder blend during TS HMG was unraveled by using a rheometer and differential...
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The effects of unintentional and intentional process disturbances on tablet quality during long continuous manufacturing runs
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Taipale-Kovalainen, Krista, Karttunen, Anssi-Pekka, Niinikoski, Hannes, Ketolainen, Jarkko, Korhonen, Ossi
Several kinds of process disturbances can occur during (continuous) tablet manufacturing, i.e. unintentional or intentional disturbances. Long run-time continuous manufacturing studies are used to investigate the effects of intentional and unintentional deviations. In this study, the horizontal...
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The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Lakerveld, R, Benyahia, BHeider, PL, Zhang, HT, Wolfe, A, Testa, CJ, Ogden, S, Hersey, DR, Mascia, S, Evans, JMB, Braatz, RD, Barton, PI
Continuous manufacturing offers potential opportunities for the improved manufacturing of pharmaceutical products. A key challenge is the development of an appropriate control strategy. The experimental application of an automated control strategy is presented for an end-to-end continuous...
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Tableting model assessment of porosity and tensile strength using a continuous wet granulation route
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Wang, Li Ge, Omar, Chalak, Li, Jianfeng, Mitchell, Niall, Bellinghausen, Stefan, Barrasso, Dana, Salman, Agba, Slade, David
This paper presents a comprehensive assessment of the most widely used tablet compaction models in a continuous wet granulation tableting process. The porosity models, tensile strength models and lubricant models are reviewed from the literature and classified based on their formulations i.e....
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Simulation-Based Design of an Efficient Control System for the Continuous Purification and Processing of Active Pharmaceutical Ingredients
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Sen, M, Singh, R, Ramachandran, R
In this study, an efficient system-wide controlsystem has been designed for the integrated continuous purification and processing of the active pharmaceutical ingredient (API). The control strategy is based on the regulatory PID controller which is most widely used in the manufacturing industry...
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Sample Mass Estimate for the Use of Near-Infrared and Raman Spectroscopy to Monitor Content Uniformity in a Tablet Press Feed Frame of a Drug Product Continuous Manufacturing Process
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Hetrick, Evan, Castillo, Ismael, Rehrla, Jakob, Sagmeistera, Peter, Lebl, René, Kruisza, Julia, Celikovic, Selma, Sipek, Martin, Williams, Myers, David P
Recently, feed frame-based process analytical technology measurements used to assure product quality during continuous manufacturing processes have received significant attention. These measurements are able to accurately determine uniformity of the powder blend before compression, and in these...
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RTD modeling of a continuous dry granulation process for process control and materials diversion
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Kruisz, Julia, Rehrl, Jakob, Sacher, Stephan, Aigner, Isabella, Horn, Martin, Khinast, Johannes G., Krumme, Markus
Disturbance propagation during continuous manufacturing processes can be predicted by evaluating the residence time distribution (RTD) of the specific unit operations. In this work, a dry granulation process was modelled and four scenarios of feeding events were simulated. We performed...
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Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Chopda, Viki, Gyorgypal, Aron Yang, Ou Singh, Ravendra Ramachandran, Rohit Zhang, Haoran Tsilomelekis, George Chundawat, Shishir PS, Ierapetritou, Marianthi G
Continuous bioprocessing is significantly changing the biological drugs (or biologics) manufacturing landscape by potentially improving product quality, process stability, and overall profitability, as was similarly seen during the adoption of advanced manufacturing processes for small molecule...
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Real-time monitoring of particle size distribution in a continuous granulation and drying process by near infrared spectroscopy
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Pauli, V, Roggo, YKleinebudde, P, Krumme, M
In continuous granulation, it can be important to control granules particle size distribution (PSD), as it may affect final product quality. Near infrared spectroscopy (NIRS) is already a routine analytical procedure within pharmaceutical continuous manufacturing for the in-line analysis of...
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Process monitoring and evaluation of a continuous pharmaceutical twin-screw granulation and drying process using multivariate data analysis
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Silva, A. F., Vercruysse, J., Vervaet, C., Remon, J. P., Lopes, J. A., De Beer, T., Sarraguca, M. C.
The present study aims at acquiring an in-depth process knowledge about a twin-screw granulation and fluid bed drying process performed on the commercially available continuous line. Batch Statistical Process Monitoring (BSPM) principles are used to describe and monitor the variables with a...
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Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Pauli, Victoria, Kleinebudde, Peter, Krumme, Markus
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production. One of the main technical challenges of CM is that the process needs to handle transient conditions such as the start-up phase...
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Pharmaceutical application of multivariate modelling techniques: a review on the manufacturing of tablets
Peer-reviewed journal | 09 Jun 2023 | Contributor(s):: Shi, Guolin, Lin, Longfei, Liu, Yuling, Chen, Gongsen, Luo, Yuting, Wu, Yanqiu, Li, Hui
The tablet manufacturing process is a complex system, especially in continuous manufacturing (CM). It includes multiple unit operations, such as mixing, granulation, and tableting. In tablet manufacturing, critical quality attributes are influenced by multiple factorial relationships between...